Dr. Safah obtained her MD from the American University of Beirut in 1987. In 1991, she completed her residency training in Internal Medicine at Greater Baltimore Medical Center in Baltimore, MD. In 1994, she completed her fellowship training in Hematology and Medical Oncology at the University of Florida.

Dr. Safah joined the faculty of Tulane University School of Medicine in 1994 as an Instructor of Medicine. The following year she was promoted to an Assistant Professor of Medicine and Associate Medical Director of the Bone Marrow Transplant Program. In 2000, she was promoted to Associate Professor of Medicine and Director of the Bone Marrow Transplant Program. She has served as the Alternate Vice Chairperson of the TUHSC Committee on the Use of Human Subjects and the Medical Director of the Institutional Review Board.